Selected Publications

home page statistics



Research Lab




About Me




Peer-Reviewed Publications (reverse chronological): {Note: The total citation number for English publications is 2911, updated on may 1, 2017 from Google Scholar. Click "Full-text" for the PDF file}.

  1. Yin C, Zhang T, Qu X, Zhang Y, Putatunda R, Xiao X, Li F, Xiao W, Zhao H, Dai S, Qin X, Mo X, Young W-B, Khalili K, Hu W, In vivo excision of HIV-1 provirus by saCas9 and multiplex sgRNAs in animal models, Molecular Therapy, doi:10.1016/j.ymthe.2017.03.012 (Full-text)
  2. Zhang Y, Li F, Xiao X, Deng W, Yin C, Zhang T, Murthy KS, Hu W*. Regulator of G protein signaling 4 is a novel target of GATA-6 transcription factor. Biochem Biophys Res Commun. 2016 Oct 13. pii: S0006-291X(16)31688-6. doi: 10.1016/j.bbrc.2016.10.024. (Full-text)
  3. D’Rozario M, Zhang T, Waddell EA, Zhang YG, Sahin C, Sharoni M, Hu T, Naya M, Kutty K, Lieb F, Hu WH*, and Marenda DR. Type I bHLH proteins Daughterless and TCF4 restrict neurite branching and synapse formation by repressing Neurexin in postmitotic neurons. Cell Reports, 2016 Apr 12;15(2):386-97 (Full-text)
  4. Feng D, Shen D, Liu F, Ohtake Y, Zhou A, Wang H, Zhang Y, Kearns A, Peng X, Zhu F, Hayat U, Li M, He Y, Xu M, Zhao C, Cheng M, Zhang L, Wang H, Yang X, Ju C, Bryda EC, Gordon J, Khalili K, Hu WH, Li S, Qin X and Gao B. Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clinical Investigation 2016 Jun 1;126(6):2321-33 (Full-text)
  5. Yin CR, Zhang T, Li F, Yang F, Putatunda R, Young WB, Khalili K, Hu WH*, and Zhang YG. Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS. AIDS, 2016 May 15;30(8):1163-74 (Full-text)
  6. Kaminski R, Chen Y, Fischer T, Tedaldi E, Napoli A, Zhang Y, Karn J, Hu WH*, Khalili K. Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Scientific Reports, 2016 Mar 4;6:22555. (Full-text)
  7. Zhang YG, Li F, Wang H, Yin CY, Huang J, Mahavadi S, Murthy KS, Hu WH*. Immune/Inflammatory Response and Hypocontractility of Rabbit Colonic Smooth Muscle After TNBS-Induced Colitis. Dig Dis Sci. 2016; 61(7):1925-40 (Full-text)
  8. McCaffrey J, Sibert J, Zhang B, Zhang Y, Hu WH, Riethman H, Xiao M. CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis.Nucleic Acids Res. 2016 Jan 29;44(2):e11. (Full-text)
  9. Zhang YG, Yin CR, Zhang T, Li F, Yang WS, Kaminski R, Fagan P, Putatunda R, Young WB, Khalili K, and Hu WH*. CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoir. Scientific Reports, 2015 Nov 5; 5:16277. (Full-text)
  10. Zhang YG, Liu S, Wang H, Yang WS, Li F, Yang F, Yu DH, Ramsey FV, Tuszyski GP, Hu WH*. Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling. OncoTarget 2015 Mar 20;6(8):6160-78 (Full-text)
  11. Hu WH*, Kaminski R, Yang F, Zhang YG, Cosentino L, Li F, Luo B,  Alvarez-Carbonell D, Garcia Y, Karn J, Mo XM, and Khalili K. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. PNAS 2014; 111(31):11461-6. (Full-text)
  12. Zhang YG, Bitner D, Pontes A, Li F, Liu S, Wang H, Yang F, Adhikari S, Gordon J, Srinivasan S, Hu WH*. Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system. Neurogastroenterology Motility 2014; 26(1):77-97. (Full-text)
  13. Zhang, Y. and Hu WH*. Mouse Enteric Neuronal Cell Culture. Neuronal Cell Culture. S. Amini and M. K. White (Ed), ISBN: 978-1-62703-639-9, Humana Press, 2013. DOI: 10.1007/978-1-62703-640-5_6. Method in Molecular Biology 2013; 1078: 55-63 (Full-text)
  14. Pontes A, Zhang Y and Hu WH*. Novel functions of GABA signaling in adult neurogenesis. Front Biol 2013; DOI 10.1007/s11515-013-1270-2 (Review)
  15. Zhang Y and Hu WH*. NFκB signaling directs neuronal fate decision. In: Wislet-Gendebien S (ed): Trends in Cell Signaling Pathways in Neuronal Fate Decision. InTech 2012, ISBN 980-953-307-601-5 (Full-text)
  16. Zhang Y and Hu WH. NFkB signaling regulates embryonic and adult neurogenesis. Front Biol 2012; DOI 10.1007/s11515-012-1233-z. (Full-text)
  17. Zhang Y, Liu J, Yao S, Li F, Xin L, Lai M, Bracchi-Ricard V, Xu H, Yen W, Meng W, Liu S, Yang L, Karmally S, Zhu H, Gordon J, Khalili K, Srinivasan S, Bethea JR, Mo X, Hu WH. Nuclear factor kappa B signaling initiates early differentiation of neural stem cells. Stem Cells 2012;30:510-524. (IF:7.871)(cited by 1) (Full-text)
  18. Zhang Y, Li F, Liu S, Wang H, Mahavadi S, Murthy KS, Khalili K, Hu WH. MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells. PLoS One 2012;7:e35646. (IF:4.411) (Full-text)
  19. Sun D, Gugliotta M, Rolfe A, Reid W, McQuiston AR, Hu WH, Young H. Sustained survival and maturation of adult neural stem/progenitor cells after transplantation into the injured brain. J Neurotrauma 2011;28:961-972. (IF:3.426) (Full-text)
  20. Li F, Murthy KS, Khalili K, Hu WH. Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle. Gene 2010;451:45-53. (IF:2.266) (cited by 3) (Full-text)
  21. Li F, Hu DY, Liu S, Mahavadi S, Yen W, Murthy KS, Khalili K, Hu WH. RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells. Am J Physiol Cell Physiol 2010;299:C1418-1429. (IF:3.817) (cited by 3) (Full-text)
  22. Kuang X, Hu WH, Yan M, Wong PK. Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice. Neurochem Int 2010;57:738-748. (IF:3.601) (cited by 2) (Full-text)
  23. Hu WH, Li F, Mahavadi S, Murthy KS. Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway. Am J Physiol Cell Physiol 2009;296:C1310-1320. (IF:3.817) (cited by 11) (Full-text)
  24. Hu WH, Li F, Mahavadi S, Murthy KS. Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle. Biochem J 2008;412:35-43. (IF:5.016) (cited by 15) (Full-text)
  25. Bracchi-Ricard V, Brambilla R, Levenson J, Hu WH, Bramwell A, Sweatt JD, Green EJ, Bethea JR. Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J Neurochem 2008;104:611-623. (IF:4.337) (cited by 19) (Full-text)
  26. Zhou H, Jarujaron S, Gurley EC, Chen L, Ding H, Studer E, Pandak WM, Jr., Hu WH, Zou T, Wang JY, Hylemon PB. HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR. Atherosclerosis 2007;195:e134-143. (IF:4.086) (cited by 21) (Full-text)
  27. Song Y, Wilkins P, Hu WH, Murthy KS, Chen J, Lee Z, Oyesanya R, Wu J, Barbour SE, Fang X. Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells. Biochem J 2007;406:427-436. (IF:5.016) (cited by 33) (Full-text)
  28. Hu WH, Mahavadi S, Li F, Murthy KS. Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta. Am J Physiol Cell Physiol 2007;293:C1991-2000. (IF:3.817) (cited by 13) (Full-text)
  29. Yan D, Li F, Hall ML, Sage C, Hu WH, Giallourakis C, Upadhyay G, Ouyang XM, Du LL, Bethea JR, Chen ZY, Yajnik V, Liu XZ. An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). J Mol Biol 2006;357:755-764. (IF:4.008) (cited by 16) (Full-Text)
  30. Huang J, Mahavadi S, Sriwai W, Hu WH, Murthy KS. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. Biochem J 2006;396:193-200. (IF:5.016) (cited by 46) (Full-Text)
  31. Hu WH, Mahavadi S, Huang J, Li F, Murthy KS. Characterization of S1P1 and S1P2 receptor function in smooth muscle by receptor silencing and receptor protection. Am J Physiol Gastrointest Liver Physiol 2006;291:G605-610. (IF:3.522) (cited by 21) (Full-Text)
  32. Hu WH, Huang J, Mahavadi S, Li F, Murthy KS. Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. Biochem Biophys Res Commun 2006;343:1038-1044. (IF:2.595) (cited by 17) (Full-Text)
  33. Hu WH, Pendergast JS, Mo XM, Brambilla R, Bracchi-Ricard V, Li F, Walters WM, Blits B, He L, Schaal SM, Bethea JR. NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. J Biol Chem 2005;280:29233-29241. (IF:5.328) (cited by 39) (Full-Text)
  34. Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005;202:145-156. (IF:14.776) (cited by 126) (Full-Text).
  35. Hu WH, Mo XM, Walters WM, Brambilla R, Bethea JR. TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. J Biol Chem 2004;279:35975-35983. (IF:5.328) (cited by 29) (Full-Text),
  36. Hu WH, Walters WM, Xia XM, Karmally SA, Bethea JR. Neuronal glutamate transporter EAAT4 is expressed in astrocytes. Glia 2003;44:13-25. (IF:5.186) (cited by 34) (Full-Text).
  37. Hu WH, Hausmann ON, Yan MS, Walters WM, Wong PK, Bethea JR. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). J Neurochem 2002;81:36-45. (IF:4.337) (cited by 35) (Full-Text)
  38. Hausmann ON, Hu WH, Keren-Raifman T, Witherow DS, Wang Q, Levay K, Frydel B, Z Slepak V, R Bethea JR. Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats. Eur J Neurosci 2002; 15(4):602-612. (IF:3.658) (cited by 11) (Full-Text).
  39. Qiang WA, Sun L, Hu WH, Zuo P, Ren MF and Liu JS. Effects of high dose of dynorphin on NMDA receptor and NOS activities in spinal cord of rats. Acta Academiae Medicinae Sinicae 2000; 22(2):134-138. (Full-Text)
  40. Hu WH, Liu N, Li F, Qiang WA, LiaoWH and Ren MF.  Effects of kappa-opioid receptor on dynorphin-induced spinal cord injury. Chin J Traumatol 2000; 16(5): 286-288. 
  41. Hu WH, Qiang WA, Li F, Liu N, Wang GQ, Wang HY, Wan XS, Liao WH, Liu JS, Jen MF. Constitutive and inducible nitric oxide synthases after dynorphin-induced spinal cord injury. J Chem Neuroanat 2000;17:183-197. IF:2.121) (cited by 17) (Full-Text)
  42. Hu WH, Johnson H, Shu HB. Activation of NF-kappaB by FADD, Casper, and caspase-8. J Biol Chem 2000;275:10838-10844. (IF:5.328) (cited by 231) (Full-Text)
  43. Zeng C, Zhu Z, Hu WH, Liu G, Zhu S, Zhou Y, Shi W. Value of sublingual isosorbide dinitrate before isoproterenol tilt test for diagnosis of neurally mediated syncope. Am J Cardiol 1999;83:1059-1063. (IF:3.681) (cited by 26) (Full-Text)
  44. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-683. (IF:4.626) (cited by 336) (Full-Text)
  45. Hu WH, Li F, Qiang WA, Liu N, Wang GQ, Xiao J, Liu JS, Liao WH, Jen MF. Dual role for nitric oxide in dynorphin spinal neurotoxicity. J Neurotrauma 1999;16:85-98. (IF:3.426) (cited by 24) (Full-Text)
  46. Hu WH, Johnson H, Shu HB. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem 1999;274:30603-30610. (IF:5.328) (cited by 211) (Full-Text)
  47. Hu WH, Yang HF, Li F, Qiang WA, Sun XJ, Liu N, Wan XST, Liu JS and Ren MF. Increases of inducible nitric oxide synthase activity and mRNA expression in rat spinal cord after dynorphin neurotoxicity. Chin J Pathophysiol 1999; 15(3):217-221. (Full-Text)
  48. Li F, Hu WH, Liu N, Qiang WA, Sun XJ,  Wan XST, Liu JS and Jen MF. Role of neuronal nitric oxide synthase in dynorphin spinal neurotoxicity and analgesia in rats. Nat. Med. J. Chin 1999; 79(3):217-220 (Full-Text)
  49. Hu WH, Zhang CH, Yang HF, Zheng YF, Liu N, Sun XJ and Jen MF. Dualistic effect of dynorphin on high potassium-induced increase of intracellular free calcium concentration in cultured rat spinal neurons. Chin J Pharmacol Toxicol 1998; 12(1):32-35
  50. Hu WH, Zhang CH, Yang HF, Zheng YF, Liu N, Sun XJ, Jen J, Jen MF. Mechanism of the dynorphin-induced dualistic effect on free intracellular Ca2+ concentration in cultured rat spinal neurons. Eur J Pharmacol 1998;342:325-332. (IF:2.737) (cited by 17) (Full-Text)
  51. Hu WH, Liu N, Sun XJ, Jen J, Yang HF and Jen MF. L-NAME aggravates dynorphin-induced spinal cord injury in rats. Chin J Neurosci 1997; 4(3):115-119
  52. Li FC, Zuo PP, Hu WH, Liu N, Jen MF. Glutamate involvement in rats with spinal cord injury induced by dynorphin A(1-17). Chin J. Rehabil. Theory and Practice 1997; 3:6-9.
  53. Hu WH. [Effects of dynorphin A1-17 on the activities, immunoreactivities and mRNA expression of cNOS and iNOS in rat spinal cord and their mechanisms]. Sheng Li Ke Xue Jin Zhan 1997;28:45-48.
  54. Hu WH, Lee FC, Wan XS, Chen YT, Jen MF. Dynorphin neurotoxicity induced nitric oxide synthase expression in ventral horn cells of rat spinal cord. Neurosci Lett 1996;203:13-16. (IF:2.055) (cited by 18) (Full-Text)
  55. Hu WH, Sun XJ, Wan XST, Liu JS and Jen MF. Intrathecal administration of NOS inhibitor L-NAME produced algesia, analgesia and paralysis in rat. Chin Pharmacol Bull 1996; 12(4):309-313
  56. Li F, Hu WH, Liao WH and Jen MF. Nitric oxide mediates NMDA neurotoxicity in rat primary spinal culture. Chin J Neurosci 1995; P245
  57. Hu WH, Yang HW, Wang YJ and Liao WH. Segmental distribution of electrocytes and water in spinal cord after ischemia-reperfusion injury in conscious rabbits. Acta Academiae Medicinae Militaris Tertiae  1995; 17(4):315-317
  58. Li FC, Sun XJ, Hu WH and Jen MF. Intrathecal coadministration of kappa opioid receptor agonists and NMDA receptor antagonist induced synergetic analgesia in rat. Acta Pharmaceutia Sinica 1994; 29(12):881-886
  59. Hu WH, Yang HW and Liao WH. The effects of neurotransmitter and non-neurotransmitter amino acids in secondary injury after spinal cord ischemia in awake rabbits. Acta Academiae Medicinae Militaris Tertiae  1994; 16(3):170-4
  60. Hu WH, Yang HW, Wang YJ and Liao WH. The effect of ion changes and edema formation during secondary injury following spinal cord ischemia in awaken rabbit. Chin J Pathophysiol 1994;10(6):659
  61. Hu WH, Yang HW, Lu XB and Liao WH.  Neurobehavioral outcome of spinal cord delayed postischemic injury in awaken rabbits. Chin J Pathophysiol 1993; 9(4):483
  62. Yang HW, Hu WH, Ding ZM and Liu YB. Changes of spinal cord blood flow after ventral spinal cord injury in rats. Chinese J Neurosurg 1991; 7(2):87
  63. Hu WH, Liu YB, Yang CQ, et al. Measurement of blood flows to gray and white matter of segmental spinal cord with radioactive biomicrosphere technique.  Chin J Neurosurg 1990



Genebank Database

1.   DQ120011 Oryctolagus cuniculus regulator of G-protein signalling 4 (RGS4) mRNA, 5' UTR and complete cdsgi|74027175|gb|DQ120011.1|[74027175]

2.   AY630620  Mus musculus NIK and IKKbetta-binding protein (Nibp) mRNA, complete cds

3.   AY630619  Homo sapiens NIK and IKKbetta-binding protein (NIBP) mRNA, partial cds

4.   AF463496 Homo sapiens NIK-associated protein mRNA, complete cds. gi|27462964|gb|AF463496.1|[27462964]

5.   AF336862 Mus musculus NOGO-interacting mitochondrial protein (NIMP) mRNA, complete cds

6.   AF336861 Homo sapiens NOGO-interacting mitochondrial protein (NIMP) mRNA, complete cds

7.   AF136294 Homo sapiens TNF and ApoL related ligand TALL-2 (TALL2) mRNA, complete cds

8.   AF136293 Homo sapiens TNF and ApoL related ligand TALL-1 (TALL1) mRNA, complete cds




This page does not reflect an official position of Temple University

This site was last updated 4/8/2017