The Effect of HS-LFA on Growth Cones
Normal Activity Effect of HS-LFA



HS-LFA (Leu, Phe, Ala) is a specific inhibitor of Matrix Metalloproteinase 2 (Gelatinase A).  When applied to retinal cells in vitro, it causes a major change in the activity of the growth cone.  Filopodial extension is inhibited, and the terminal of the axon becomes swollen, with occasional small blebs that form and then retract. (Sheffield, Krasnopolsky and Dehlinger, Devel. Dyn. 200:79, 1994)

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