The control of chemical reactivity using laser pulses has been a focus for the chemical physics community since the laser was developed forty years ago.  Recently a string of experiments have demonstrated quantum control using shaped laser pulses.  Common to each of these experiments is the use of the closed-loop algorithm to determine the optimal pulse shape for a particular goal.  The closed-loop concept introduced into the quantum control field by the Rabitz group in 1992.  In the closed-loop experiment the outcome of the interaction of a series of shaped laser pulses with a molecule is fed directly into a computer to determine the next series of pulses that will interact with the molecule to produce the desired result.  In this experiment, the molecule directs the interactive process that finds the optimal laser pulse.  Most recently the Levis group demonstrated the selective cleavage and rearrangement of organic molecules using shaped, strong field laser pulses(Science, 292, 709, 2001).  More information regarding these investigations can be found in publications link.