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Publications Since 1995
Ferrante, L. S. & Woodruff-Pak, D. S. (1995). Longitudinal
investigation of eyeblink classical conditioning in the old-old.
Journal of Gerontology: Psychological Science, 50B, P42-50.
Woodruff-Pak, D. S. (1995). Evaluation of cognition-enhancing
drugs: Utility of the model system of eyeblink classical conditioning.
CNS Drug Reviews, 1, 107-128.
Woodruff-Pak, D. S. & Hanson, C. (1995). Neuronal plasticity,
brain compensation, and brain memory systems. In R. Dixon & L. Backman
(Eds.), Psychological compensation: Managing losses and promoting gains
(pp. 191-217). Hillsdale, NJ: Erlbaum.
Simon, E. W., Rappaport, D. A., Papka, M., & Woodruff-Pak, D. S.
(1995). Fragile X and Down Syndrome: Are there syndrome specific
cognitive profiles at low IQ levels? Journal of Mental Deficiency
Research, 39, 326-330.
Woodruff-Pak, D. S. & Finkbiner, R. G. (1995). Larger
nondeclarative than declarative deficits in learning and memory in
human aging. Psychology and Aging, 10, 416-426.
Papka, M., Ivry, R. B., & Woodruff-Pak, D. S. (1995). Selective
disruption of eyeblink classical conditioning by concurrent tapping.
NeuroReport, 6, 1493-1497.
Woodruff-Pak, D. S. & Finkbiner, R. G. (1995). One-day retention
of eyeblink classical conditioning and verbal free recall in young and
older adults. Aging and Cognition, 2, 108-127.
Woodruff-Pak, D. S., Romano, S., & Papka, M. (1996). Training to
criterion in eyeblink classical conditioning in Alzheimer's disease,
Down's syndrome with Alzheimer's disease, and healthy elderly.
Behavioral Neuroscience, 110, 22-29.
Woodruff-Pak, D. S. & Trojanowski, J. Q. (1996). The older rabbit
as an animal model: Implications for Alzheimer's disease. Neurobiology
of Aging. 17, 283-290.
Papka, M. & Woodruff-Pak, D. S. (1996). Number of trials needed
to assess human eyeblink classical conditioning. Psychology and Aging.
11, 373-376.
Woodruff-Pak, D. S. & Papka, M. (1996). Alzheimer's disease and
eyeblink conditioning: 750 ms trace versus 400 ms delay paradigm.
Neurobiology of Aging. 17, 397-404.
Woodruff-Pak, D. S., Papka, M., Romano, S., & Li, Y.-T. (1996).
Eyeblink classical conditioning in Alzheimer's disease and
cerebrovascular dementia. Neurobiology of Aging. 17, 505-512.
Woodruff-Pak, D. S. & Port, R. L. (1996). Conditioning. In J. E.
Birren (Ed.), Encyclopaedia of Gerontology (pp.319-327), San Diego:
Academic Press.
Woodruff-Pak, D. S. & Papka, M. (1996). Huntington's disease and
eyeblink classical conditioning: Normal learning but abnormal timing.
Journal of the International Neuropsychological Society, 2, 323-334.
Woodruff-Pak, D. S., Papka, M., & Ivry, R. B. (1996). Cerebellar
involvement in eyeblink classical conditioning in humans.
Neuropsychology, 10, 443-458.
Woodruff-Pak, D. S., Romano, S. J., & Hinchliffe, R. M. (1996).
Detection of Alzheimer's disease with eyeblink classical conditioning
and the pupil dilation response. Alzheimer's Research, 2, 173-180.
Woodruff-Pak, D. S. (1997). Nefiracetam ameliorates learning
deficits in older rabbits and may act via hippocampus. Behavioural
Brain Research, 83, 179-184.
Woodruff-Pak, D. S., Li, Y.-T., Hinchliffe, R. M. & Port, R. L.
(1997). Hippocampus in delay eyeblink classical conditioning: Essential
for nefiracetam amelioration of leaning in older rabbits.
Brain Research, 747, 207-218.
Woodruff-Pak, D. S. & Hinchliffe, R. M. (1997). Scopolamine- or
mecamylamine-induced learning impairment: Reversed by nefiracetam.
Psychopharmacology, 131, 130-139.
Woodruff-Pak, D. S. (1997). Classical conditioning. R. J.
Bradley, R. A. Harris, & P. Jenner (Series Eds.) International Review
of Neurobiology, Vol. 41, J. D. Schmahmann (Ed.), The cerebellum and
cognition (pp. 341-366). San Diego, Academic Press.
Papka, M., Ivry, R. B., & Woodruff-Pak, D. S. (1997). Eyeblink
classical conditioning and awareness revisited: Results of a dual-task
study. Psychological Science, 8, 404-408.
Green, J. T. & Woodruff-Pak, D. S. (1997). Concurrent eyeblink
classical conditioning and rotary pursuit performance: Implications for
independent nondeclarative systems. Neuropsychology, 11, 474-487.
Woodruff-Pak, D. S., Chi, J., Li, Y.-T., Pak, M. H., & Fanelli,
R. J. (1997). Nimodipine ameliorates impaired eyeblink classical
conditioning in older rabbits in the long-delay paradigm, Neurobiology
of Aging.. 18, 641-649.
Woodruff-Pak, D. S. & Jaeger, M. E. (1998). Predictors of
eyeblink classical conditioning over the adult age span. Psychology and
Aging, 13, 193-205.
Woodruff-Pak, D. S. & Papka, M. (1999). Theories of
neuropsychology and aging. In V. L. Bengtson & K. W. Schaie (Eds.).
Handbook of theories of aging (pp. 113-132). New York: Springer
Publishing Co.
Woodruff-Pak, D. S. (1999). New directions for a classical
paradigm: Eyeblink conditioning. Psychological Science. 10, 1-3.
Green, J. T., Ivry, R. B., & Woodruff-Pak, D. S. (1999).
Timing in eyeblink classical conditioning and timed-interval tapping.
Psychological Science, 10, 20-24.
Woodruff-Pak, D. S., Jaeger, M. E., Gorman, C., & Wesnes, K. A.
(1999). Relationships among age, CS-US interval, and neuropsychological
test performance. Neuropsychology, 13, 90-102.
Downey-Lamb, M. M. & Woodruff-Pak, D. S. (1999). Early
detection of cognitive deficits using eyeblink classical
conditioning. Alzheimer’s Reports, 2, 411-418.
Mostofsky, S. H., Green, J. T., Meginley, M., Christensen,
J. R. & Woodruff-Pak, D. S. (1999).Conditioning in identical twins with
ataxia-telangiectasia. Neurocase,5, 425-433.
Green, J. T., Small, E. M., Downey-Lamb, M. M., & Woodruff-Pak,
D. S. (1999). Dual task performance of eyeblink classical conditioning
and visual repetition priming: Separate brain memory systems.
Manuscript in revision.
Woodruff-Pak, D. S. Green, J. T., Pak, J. T., Heifets, B., &
Pak, M. H. (1999). The effect of nefiracetam on eyeblink classical
conditioning in the scopolamine-injected older rabbit. Manuscript
submitted for publication.
Green, J. T. & Woodruff-Pak,D. S. (2000). Eyeblink classical
conditioning: Hippocampal formation is for neutral stimulus
associations as cerebellum is for association-response.
Psychological Bulletin, 126, 138-158.
Woodruff-Pak, D. S., Green, J. T., Coleman-Valencia, C., &
Pak, J. T. (2000). A nicotinic cholinergic agonist (GTS-21) and eyeblink
classical conditioning: Acquisition, retention,and relearning in
older rabbits. Experimental Aging Research,26, 323-336.
Woodruff-Pak, D. S. Goldenberg, G., Downey-Lamb, M. M., Boyko,
O. B., & Lemieux, S. K. (2000). Cerebellar volume in humans related
to magnitude of classical conditioning. NeuroReport, 14, 609-615.
Green, J. T. & Woodruff-Pak, D. S. (2000). Eyeblink classical
conditioning: Hippocampus is for multiple associations as cerebellum
is for association-response. Psychological Bulletin, 126, 138-158.
Woodruff-Pak, D. S. & Steinmetz, J. E. (2000). Past, present,
and future of human eyeblink classical conditioning. In D. S.
Woodruff-Pak & J. E. Steinmetz (Eds.), Eyeblink Classical
Conditioning: Volume I, Applications in Humans (pp. 1-17). Boston:
Kluwer.
Lemieux, S. K. & Woodruff-Pak, D. S. (2000). Functional
magnetic resonance imaging studies of eyeblink classical conditioning.
In D. S. Woodruff-Pak & J. E. Steinmetz (Eds.), Eyeblink Classical
Conditioning: Volume I, Applications in Humans (pp. 71-93). Boston:
Kluwer.
Green, J. T., Woodruff-Pak, D. S., & Ivry, R. B. (2000).
Dual-task and repeated measurement designs: Utility in assessing
timing in eyeblink conditioning. In D. S. Woodruff-Pak & J. E.
Steinmetz (Eds.), Eyeblink Classical Conditioning: Volume I,
Applications in Humans (pp. 95-117). Boston: Kluwer.
Woodruff-Pak, D. S. (2000). Eyeblink classical conditioning in
normal aging and Alzheimer's disease. In D. S. Woodruff-Pak & J. E.
Steinmetz (Eds.), Eyeblink Classical Conditioning: Volume I,
Applications in Humans (pp. 163-189). Boston: Kluwer.
Steinmetz, J. E. & Woodruff-Pak, D. S. (2000). Animal models
in eyeblink classical conditioning: From mice to non-human primates.
In D. S. Woodruff-Pak & J. E. Steinmetz (Eds.), Eyeblink Classical
Conditioning: Volume II, Animal Models (pp. 1-15). Boston: Kluwer.
Green, J. T. & Woodruff-Pak, D. S. (2000). Eyeblink classical
conditioning in aging animals. In D. S. Woodruff-Pak & J. E. Steinmetz
(Eds.), Eyeblink Classical Conditioning: Volume II, Animal Models (pp.
155-178). Boston: Kluwer.
Woodruff-Pak, D. S. & Ewers, M. (2000). Cognition-enhancing
drugs and eyeblink conditioning. In D. S. Woodruff-Pak & J. E.
Steinmetz (Eds.), Eyeblink Classical Conditioning: Volume I, Animal
Models (pp. 335-356). Boston: Kluwer.
Woodruff-Pak, D. S. & Santos, I. (2000). Nicotinic modulation
in an animal model of a form of associative learning impaired in
Alzheimer's disease. Behavioural Brain Research, 113, 11-19.
Woodruff-Pak, D. S., Green, J. T., Coleman-Valencia, C., &
Pak, J. T. (2000). A nicotinic cholinergic drug (GTS-21) and eyeblink
classical conditioning: Acquisition, retention, and relearning in
older rabbits. Experimental Aging Research, 26, 323-336.
Woodruff-Pak, D. S. (2001). Simultaneous conditioning. In W.
E. Craighead & C. B. Nemeroff (Eds.), Encyclopedia of Psychology and
Neuroscience (3rd ed.). New York: John Wiley & Sons.
Woodruff-Pak, D. S., Vogel, R. W. III, & Wenk, G. L. (2001).
Galantamine: Effect on nicotinic receptor binding,
acetylcholinesterase inhibition, and learning. Proceedings of the
National Academy of Science (USA), 98, 2089-2094.
Woodruff-Pak, D. S. & Lemieux, S. K. (2001). The cerebellum
and associative learning: Parallels and contrasts in rabbits and
humans. In J. E. Steinmetz, M. A. Gluck, & P. R. Solomon (Eds.),
Model Systems and the Neurobiology of Associative Learning: A
Festschrift in Honor of Richard F. Thompson (pp. 271-294). Mahwah, NJ:
Erlbaum.
Woodruff-Pak, D. S. (2001). Eyeblink classical conditioning
differentiates normal aging from Alzheimer's disease. Integrative
Physiological and Behavioral Science, 36, 87-108.
Woodruff-Pak, D. S. (2001). Insights about learning in
Alzheimer's disease from the animal model. In M. E. Carroll & J. B.
Overmier (Eds.), Linking Animal Research and Human Psychological Health
(pp. 323-336). Washington, D. C.: American Psychological Association.
Woodruff-Pak, D. S., Vogel, R. W. III, Ewers, M., Coffey, J.,
Boyko, O. B., & Lemieux, S. K. (2001). MRI-assessed volume of
cerebellum correlates with associative learning. Neurobiology of
Learning and Memory, 76, 342-357.
Woodruff-Pak, D. S. & Lemieux, S. K. (2001). Memory and aging,
neural basis of. In N. J. Smelser & P. B. Baltes (Eds.) International
Encyclopedia of the Social & Behavioral Sciences. Oxford: Pergamon.
Woodruff-Pak, D. S. & Gould, T. J. (2002). Neuronal nicotinic
acetylcholine receptors: Involvement in Alzheimer's disease and
schizophrenia. Behavioral and Cognitive Neuroscience Reviews, 1, 5-20.
Pak, J. T., Green, J. T., Heifets, B., Pak, M. H., &
Woodruff-Pak, D. S. (2002). Nefiracetam ameliorates associative
learning impairment in the scopolamine-injected rabbit. Medical Science
Monitor, 8, 105-112.
Woodruff-Pak, D. S., Green, J. T., Pak, J. T., Heifets, & Pak,
M. H. (2002). The effect of scopolamine in older rabbits tested in the
750 ms delay eyeblink classical conditioning procedure. Integrative
Physiological & Behavioral Science, 37, 103-113.
Woodruff-Pak, D. S. (2002). Learning. In D. J. Ekerdt, R. A.
Applebaum, K. C. Holden, S. G. Post, K. Rockwood, R. Schulz, R. L.
Sprott, & P. Uhlenberg (Eds). Encyclopedia of Aging. New York:
Macmillan Reference USA.
Woodruff-Pak, D. S. (2002). Preclinical experiments on
cognition-enhancement in Alzheimer's disease: Drugs affecting
nicotinic acetylcholine receptors. Drug Development Research, 56,
335-346.
Woodruff-Pak, D. S., Green, J. T., Pak, J. T., Shiotani, T.,
Watabe, S., & Tanaka, S. (2002). The long-term effects of nefiracetam
on learning in older rabbits. Behavioural Brain Research, 136, 299-308.
Vogel, R. W., Ewers, M., Ross, C., Gould, T. J., &
Woodruff-Pak, D. S. (2002). Age-related impairment in the
250-millisecond delay eyeblink classical conditioning procedure in
C57BL/6 mice. Learning & Memory, 9, 321-336.
Woodruff-Pak, D. S., Lander, C., & Geerts, H. (2002).
Nicotinic cholinergic modulation: Galantamine as a prototype. CNS Drug
Reviews, 8, 405-426.
Woodruff-Pak, D. S. (2003). Aging and memory in animals.
In J. H. Byrne, H. Eichenbaum, H. Roediger III, & Richard F. Thompson
(Eds), Learning and Memory, 2nd Edition (pp. 6-10). New York: Macmillan
Reference USA.
Woodruff-Pak, D. S., Vogel, R. W. III, & Wenk, G. L. (2003).
Mecamylamine interactions with galantamine and donepezil: Effects on
learning, acetylcholinesterase, and nicotinic acetylcholine
receptors. Neuroscience, 117, 439-447.
Woodruff-Pak, D. S. (2003). Mecamylamine reversal by nicotine
and by a partial alpha 7 nicotinic acetylcholine receptor agonist (GTS-21)
in rabbits tested with delay eyeblink classical conditioning. Behavioural
Brain Research, 143, 159-167.
Woodruff-Pak, D. S. (2004). Preclinical studies of galantamine
using a form of associative learning severely impaired in Alzheimer’s
disease. In A. Shamir (Ed.), Cholinergic mechanisms. London: Martin
Dunitz Ltd.
Woodruff-Pak, D. S., Ewers, M., Shiotani, T., Watabe, S., Tanaka,
M., & Wenk, G. L. (2004). Nefiracetam and physostigmine: Separate and
combined effects on learning in older rabbits. Neurobiology of Aging, 25,
807-816.
Wevers, A. K. L. & Woodruff-Pak, D. S. (2004). Rationale and
prospects for drugs that target nicotinic acetylcholine receptors. In
J. J. Buccafusco (Ed.). Cognitive Enhancing Drugs. Birkhauser Publishing
Co.
Woodruff-Pak, D.S. Green, J.T., Levin, S.I., & Meisler, M.H.
(2006). Inactivation of sodium channel Scn8A (Na v1.6) in purkinje
neurons impairs learning in morris water maze and delay but not trace
eyeblink classical conditioning. Behavioral Neuroscience, 120, 229-240.
Ewers, M., Morgan, D., Gordon, M., & Woodruff-Pak, D. S.
(2006 in press). Associative and motor learning in 12-month-old
transgenic APP + PS1 mice. Neurobiology of Aging
