Jaeseung Kim, Gregory Hewitt, Patrick Carroll and Scott McN. Sieburth, " Silanediol Inhibitors of Angiotensin-Converting Enzyme (ACE). Synthesis and Evaluation of Four Diastereomers of Phe[Si]Ala Dipeptide Analogues", Journal of Organic Chemistry, 2005 70, in the press. (cover issue, July 15).
Scott McN. Sieburth, "Photocycloaddition of alkenes (dienes) to dienes [4+4]/[4+4]" in Synthetic Organic Photochemistry, A. G. Griesbeck and J. Mattay, eds., 2004, Chapter 9, 236–258.
Guodong Liu and Scott McN. Sieburth, "alpha-Trialkylsilyl Amino Acid Stability." Organic Letters, 2005, 6, 665-668.
Scott McN. Sieburth, "Photochemical Reactivity of Pyridones" in CRC Handbook of Organic Photochemistry and Photobiology, W. Horspool, Ed., 2nd Ed., CRC, 2005, pp 103/1 – 103/18.
Jaeseung Kim and Scott McN. Sieburth, "Silanediol Peptidomimetics. Evaluation of Four Diastereomeric ACE Inhibitors.." Bioorganic and Medicinal Chemistry Letters, 2004, 14, 2853-2856.
Jaeseung Kim and Scott McN. Sieburth, "A Silanediol Inhibitor of the Metalloprotease Thermolysin: Synthesis and Comparison with a Phosphinic Acid Inhibitor." Journal of Organic Chemistry 2004, 69, 3008-3014.
Guodong Liu and Scott McN. Sieburth, "Enantioselective ?-Silyl Amino Acid Synthesis by Reverse-Aza-Brook Rearrangement." Organic Letters 2003, 5, 4677 - 4679.
Scott McN. Sieburth, Heather K. O'Hare, Jiaji Xu, Yanping Chen and Guodong Liu, "Asymmetric Synthesis of a-Amino Allyl, Benzyl and Propargyl Silanes by Metalation and Rearrangement " Organic Letters 2003, 5, 1859-1861.
Jaeseung Kim, Athanasios Glekas and Scott McN. Sieburth, "Silanediol-Based Inhibitor of Thermolysin" Bioorganic and Medicinal Chemistry Letters, 2002, 12, 3625-3627
Yanping Chen and Scott McN. Sieburth, "A New b-Keto Amide Synthesis" Synthesis 2002, 2191-2194.
Yeon-Hee Lim, Kevin F. McGee, Jr. and Scott McN. Sieburth, "Studies in Bicyclo[3.1.0]hexane Methanolysis. Ring Opening of Activated Cyclopropanes under Acidic and Basic Conditions" Journal of Organic Chemistry 2002, 67, 6535-6538.
Mwangi wa Mutahi, Thomas Nittoli, Luxuan Guo and Scott McN. Sieburth, "Silicon-Based Metalloprotease Inhibitors: Synthesis and Evaluation of Silanol and Silanediol Peptide Analogs as Inhibitors of Angiotensin-Converting Enzyme (ACE)" Journal of the American Chemical Society, 2002, 124, 7363-7375.
Scott McN. Sieburth, "SymmetryBreaking in 2-Pyridone Photoadducts. Complex Intermediates from Simple Aromatics" Proceedings of the International Conference on Research Trends in Science and Technology, 2002, 33-39.
Man Zhu, Zhiliu Qiu, Gary P. Hiel and Scott McN. Sieburth, "Photocycloaddition of Four-Carbon-Tethered Pyridones. Intramolecular Hydrogen Bonding and Facilitated Amide Hydrolysis by a Proximal Secondary Alcohol" Journal of Organic Chemistry, 2002, 67, 3487-3493.
Chien-An Chen, Scott McN. Sieburth, Athanasios Glekas, Gregory W. Hewitt, George L. Trainor, Susan Erickson-Viitanen, Sena S. Garber, Beverly Cordova, Susan Jeffries, and Ronald M. Klabe, "Drug Design with a New Transition State Analog of the Hydrated Carbonyl: Silicon-Based Inhibitors of the HIV Protease" Chemistry & Biology, 2001, 8, 1161-1166.
Yanping Chen, Tindy Li and Scott McN. Sieburth, "Pyridone Annulation by 4+2 Coupling of Dienolates with Nitriles and Nitrile Equivalents.A Solution to the Acetonitrile Problem" Journal of Organic Chemistry, 2001, 66, 6826-6828.
Scott McN. Sieburth, Christina B. Madsen-Duggan and Fangning Zhang, "Diastereoselectivity During 2-Pyridone Photo-[4 + 4] Cycloaddition. The Tribenzylsilyl Protecting Group" Tetrahedron Letters, 2001, 42, 5155-5157.
Tammy A. Aeter, Christine A. Champey, Larissa V. Kuznetsova, Tindy Li, Yeon-Hee Lim, David Rucando and Scott McN. Sieburth, "Polyquinanes by [4 + 4] Cycloaddition?Transannular Cyclization" Organic Letters, 2001, 3, 2165-2167.
Athanasios Glekas and Scott McN. Sieburth, "Studies in Silanol Synthesis: Internal Nucleophiles and Steric Hindrance" Tetrahedron Letters, 2001, 42, 3799-3801.
Kevin F. McGee, Jr., Taleb H. Al-Tel and Scott McN. Sieburth,"Fusicoccin Synthesis by Intramolecular [4 + 4] Photocycloaddition of 2-Pyridones: Stereocontrol of the Cycloaddition and Elaboration of the Pentacyclic Product" Synthesis, 2001, 1185-1196.
Gregory W. Hewitt, Joseph J. Somers and Scott McN. Sieburth,"Synthesis of a-Alkyl-a-Aminosilanes by Rhodium-Catalyzed Hydrosilylation of Boc-Protected Vinyl amines" Tetrahedon Letters 2000, 41, 10175-10179.
Yong-gyun Lee, Kevin F. McGee, Jr., Jianhao Chen, Dave Rucando and Scott McN. Sieburth, "A [4 + 4] 2-Pyridone Approach to Taxol. 3. Stereocontrol During Elaboration of the Cyclooctane " Journal of Organic Chemistry, 2000, 65, 6676-6681.
Scott McN. Sieburth, Kevin F. McGee, Jr., Fangning Zhang and Yanping Chen, "Photoreactivity of 2-Pyridones with Furan, Benzene and Naphthalene.Inter- and Intramolecular Photocycloadditions." Journal of Organic Chemistry, 2000, 65, 1972-1977.
Scott McN. Sieburth, and Kevin F. McGee, Jr., "Solvent-Dependent Stereoselectivity of Bis-2-Pyridone [4 + 4] Photocycloaddition is Due to H-Bonded Dimers." Organic Letters, 1999, 1, 1775-1777.
Scott McN. Sieburth, Kevin F. McGee, Jr. and Taleb H. Al-Tel, "Fusicoccin Ring System by [4 + 4] Cycloaddition. 2. A Model Study." Tetrahedron Letters, 1999, 40, 4007-4010.
Scott
McN. Sieburth, and Fangning Zhang, "Intramolecular Photocycloaddition of
1,3-Dienes with 2-Pyridones." Tetrahedron Letters,1999,
40,
3527-2530.
Scott
McN. Sieburth and Jerome Lang, "A Practical Synthesis of Difunctional Organosilane
Reagents and Their Application to the Diels-Alder Reaction." Journal
of Organic Chemistry, 1999,
64,1780-1781.
Scott
McN. Sieburth, David Rucando and Chao-Hsiung Lin, "Selective Intermolecular
Photo-[4 + 4]-Cycloaddition with 2-Pyridone Mixtures.3.Synthetic
Transformations of the Trans-Cross Product (1a,2b,5b,6a)-3-Butyl-9-methoxy-3,7-diazatricyclo[4.2.2.22,5]dodeca-9,11-diene-4,8-dione."
Journal
of Organic Chemistry, 1999,
64,
954-959.
Scott McN. Sieburth, Chao-Hsiung Lin and David Rucando, "Selective Intermolecular Photo-[4 + 4]-Cycloaddition with 2-Pyridone Mixtures.2.Preparation of (1a,2b,5b,6a)-3-Butyl-9-methoxy-3,7-diazatricyclo[4.2.2.22,5]dodeca-9,11-diene-4,8-dione." Journal of Organic Chemistry, 1999, 64, 950-953.
Tom Nittoli, Geoffrey Coast and Scott McN. Sieburth,"Evidence for Helicity in Insect Diuretic Peptide Hormones: Computational Analysis and Spectroscopic Studies." The Journal of Peptide Research1999, 53, 99-108.
Scott McN. Sieburth, "The Inter- and Intramolecular [4 + 4] Photocycloaddition of 2-Pyridones and Its Application to Natural Product Synthesis" in Advances in Cycloaddition, Volume 5, M. Harmata, Ed., Jai Press: Greenwich, Connecticut, 1999, pp 85-118.
Daren Krebsbach, Herbert Gelernter and Scott McN. Sieburth, "Distributed Heuristic Synthesis Search." Journal of Chemical Information and Computer Sciences, 1998, 38, 595-604.
Scott McN. Sieburth, Thomas Nittoli, Alfred M. Mutahi and Luxuan Guo, "Silanediols: A New Class of Potent Protease Inhibitors." Angewandte Chemie1998 110, 845-847. Angewandte Chemie International Edition, 1998, 37, 812-814.
Scott McN. Sieburth, Kevin F. McGee, Jr. and Taleb. H. Al-Tel, "The Fusicoccin Ring System by [4 + 4] Cycloaddition. Control of Diastereoselectivity Through Hydrogen Bonding." Journal of the American Chemical Society.1998, 120, 587-588.
Scott McN. Sieburth, Taleb H. Al-Tel, and David Rucando, "Beyond the Medium Ring: A [4 + 4] Cycloaddition/Fragmentation Synthesis of Eleven-Membered Rings" Tetrahedron Letters 1997, 38, 8433-8434.
Scott
McN. Sieburth, Joseph J. Somers, Heather K. O'Hare, and Gregory W. Hewitt,
PACIFICHEM Symposium: "a-Alkyl-a-aminosilanes:
Synthesis via Alkylation and Hydrosilylation." Applied Organometallic
Chemistry1997,
11,
337-343.
Louis Fensterbank, Max Malacria and Scott McN. Sieburth, "Intramolecular Reactions of Temporarily Silicon-Tethered Molecules" Synthesis, 1997, 813-854.
Scott McN. Sieburth, Jianhao Chen, Krishnamurthy Ravindran, and Jian-long Chen, "A 2-Pyridone Photo-[4 + 4] Approach to the Taxanes." Journal of the American Chemical Society 1996,118, 10803-10810.
Scott McN. Sieburth and Brian Siegel, "Tether-enforced reversal of regioselectivity: Head-to-head [4 + 4] photocycloaddition of 2-pyridones." Journal of the Chemical Society, Chemical Communications 1996, 2249-2250.
Scott McN. Sieburth and Joseph J. Somers, "a-Alkyl-a-aminosilanes.2.A 2H NMR Study of Organolithium Stabilization by Silicon and by Phenyl in Solution." Tetrahedron 1996, 52, 5683-5690.
Scott McN. Sieburth and Nicholas T. Cunard, "The [4+4] Cycloaddition and its Strategic Application in Natural Product Synthesis" Tetrahedron, 1996, 52, 6251-6282.
Scott
McN. Sieburth and Joseph J. Somers, and Heather K. O'Hare, "a-Alkyl-a-aminosilanes.
1. Metalation and Alkylation Between Silicon and Nitrogen." Tetrahedron1996,
52,
5669-5682.
Scott McN. Sieburth and Chao-Hsiung Lin, "Intermolecularly Selective [4+4] hotocycloaddition of 2-Pyridone Mixtures." Tetrahedron Letters1996, 37, 1141-1144.
Scott McN. Sieburth, "Isosteric Replacement of Carbon with Silicon in the Design of Safer Chemicals." Designing Safer Chemicals, S. C. DeVito and R. L. Garrett, Eds.;ACS Symposium Series 640: American Chemical Society: Washington, D.C., 1996; Chapter 4, pp. 74-83.
Scott McN. Sieburth and Chien-An Chen, "Tandem Asymmetric Alkylation—Dieckmann Condensation." Synlett 1995, 928-930
Scott McN. Sieburth and Gary Hiel, "Methylenecyclopropane." in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Chichester, 1995.
Scott McN. Sieburth and Louis Fensterbank, "2-Methyl-1-propenyl trifluoromethane sulfonate." in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Chichester, 1995.
Scott McN. Sieburth and Elena Doval Santos, "2,2,2-Trichloro-t-butoxycarbonyl chloride." in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Chichester, 1995.
Scott McN. Sieburth, "Oxazole." in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Chichester, 1995.
Scott McN. Sieburth, "4-Phenyloxazole." in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Chichester, 1995.
Thomas
G. Cullen, Scott McN. Sieburth, Jane A. Dybas, Michael A. Walsh, Gary A.
Meier, and John F. Engel, "Novel 1-Cyclopropyl-1-(4-substituted phenyl)-4-cyano-(4-fluoro-3-phenoxyphenyl)butane
Insecticides." Synthesis and Chemistry of Agrochemicals IV,
D. R. Baker, J. G. Fenyes and G. S. Basarab, Eds.;ACS
Symposium Series 584: American Chemical Society: Washington, D.C., 1994;
Chapter 22, pp. 245-254.
Gary A. Meier, Thomas G. Cullen, Scott McN. Sieburth, Katherine A. Boyler, Saroj Sehgel, Dominic P. Suarez, and Al Fritz."Insecticidal 1-Cyclopropyl-1,4-diarylbutenes and 1,4-Diarylbutanes,"Synthesis and Chemistry of Agrochemicals IV , D.R. Baker, J.G. Fenyes, G. S. Basarab, Eds.; ACS Symposium Series 584:American Chemical Society: Washington, DC, 1994; Chapter 21, pp. 236-244.
Scott McN. Sieburth and Elena Doval Santos, "A Short Synthesis of the Tricyclo-[3.3.21,4.0]decane Ring System." Tetrahedron Letters1994, 35, 8127-8130.
Scott McN. Sieburth, "Boat versus Half-chair Cyclohexyl Rings: Determinants of Conformational Preference." Journal of the Chemical Society, Chemical Communications 1994, 1663-1664.
Scott
McN. Sieburth and Chao-Hsiung Lin, "Stereocontrol of 2-Pyridone [4+4] Photocycloaddition:
A Thermal-Photochemical Cycle to Produce Exclusively Trans Cycloadducts."
Journal
of Organic Chemistry 1994,
59,
3597-3599.
Scott McN. Sieburth and K. Ravindran, "The BC Rings of Taxol by [4+4] Photocycloaddition." Tetrahedron Letters 1994, 35, 3861-3864.
Scott McN. Sieburth, Gary Hiel, Chao-Hsiung Lin and Dora P. Kuan, "Intramolecular [4+4] Photocycloaddition of 2-Pyridones Tethered by a Three-Carbon Chain: Studies on the Formation of Cycloadducts and Control of Stereogenesis. 3." Journal of Organic Chemistry 1994, 59, 80-87.
Scott
McN. Sieburth and Weilin Mu, "Silanol Synthesis: The Reaction of Hexaphenyl-cyclotrisiloxane
with Organometallic Reagents." Journal of Organic Chemistry 1993,
58,
7584-7586.
Scott McN. Sieburth and Louis Fensterbank, "Silanol Reactivity: Evaluation of Silanolate as a Metalation Directing Group." Journal of Organic Chemistry 1993, 58, 6314-6318.
Scott McN. Sieburth and Pramod V. Joshi, "Intramolecular [4+4] Photocycloadditions: Substituent-Mediated Product Control," Journal of Organic Chemistry 1993, 58, 1661-1663.
Thomas G. Cullen, S. M. Sieburth, John F. Engel, Gary A. Meier, Albert C. Lew, Susan E. Burkhart, Francis L. Marek and John H. Strickland, "1,4-Diaryl-1-Cyclopropylbutanes: Highly Efficacious Insecticides with Low Fish Toxicity," Synthesis and Chemistry of Agrochemicals III, D. R. Baker, J. G. Fenyes and J. J. Steffens, Eds.; ACS Symposium Series 504: American Chemical Society, Washington, D.C., 1992; Chapter 24, pp. 271-282.
Scott McN. Sieburth, Syed F. Ali, Charles M. Langevine and Robert H. Tullman, "Stereoselective Synthesis of Hydroxylated Bifenthrin Isomers", Bioorganic & Medicinal Chemistry Letters, 1992, 2, 1585-1588.
Gary A. Meier, Thomas G. Cullen, Saroj Sehgel, John F. Engel, Susan E. Burkart, Scott McN. Sieburth and Charles M. Langevine, "Highly Efficacious Non-ester Pyrethroid Insecticides with Low Toxicity to Fish." Synthesis and Chemistry of Agrochemicals III, D. R. Baker, J. G. Fenyes and J. J. Steffens, Eds.; ACS Symposium Series 504: American Chemical Society, Washington, D.C., 1992; Chapter 23, pp. 258-270.
Scott McN. Sieburth and Louis Fensterbank, "An Intramolecular Diels-Alder Reaction of Vinylsilanes." Journal of Organic Chemistry 1992, 57, 5279-5281.
Scott McN. Sieburth and Jian-long Chen, "A Photochemical [4+4] Method for the Construction of Annulated Eight-Membered Rings." Journal of the American Chemical Society1991, 113, 8163-8164.
Scott McN. Sieburth, Sarah Y. Lin, John F. Engel, Jane A. Greenblatt, Susan E. Burkart and Derek W. Gammon, "Silane Analogs of MTI-800: Biology and Chemistry", In Recent Advances in the Chemistry of Insect Control II, L. Crombie, Ed.; Royal Society of Chemistry, London, 1990, pp. 142-150.
Scott McN. Sieburth, Sarah Y. Lin and Thomas G. Cullen, "New Insecticides by Replacement of Carbon with Other Group IV Elements", Symposium Proceedings from 'Isosteric Replacements in Drug & Pesticide Chemistry - 6 June 1989', Pesticide Science 1990, 29, 215-225.
Scott McN. Sieburth, Charles M. Langevine, and David M. Dardaris, "Organosilane Insecticides 2: Chemistry and Structure-Activity Relationships", Pesticide Science 1990, 28, 309-319.
Scott McN. Sieburth, Charles J. Manly, and Derek W. Gammon, "Organosilane Insecticides 1:Biological and Physical Effects of Isosteric Replacement of Silicon for Carbon in Ethofenprox and MTI-800", Pesticide Science 1990, 28, 289-307.
A. E. Lund, D. W. Gammon, S. McN. Sieburth, M. A. Brown, M. E. Schroeder, and K. R. Jennings, "Role of Biochemical, Physiological, and Neurochemical Research in the Insecticide Discovery Process," Sites of Action for Neurotoxic Pesticides, R. M. Hollingsworth and M. B. Green, eds., ACS Symposium Series 356, American Chemical Society, Washington, 1987, pp. 316-325.
Paul A. Wender, Dennis A. Holt and Scott McN. Sieburth, "2-Alkenyl Carbinols from 2-Halo Ketones: 2-E-Propenylcyclohexanol." Organic Syntheses1986, 64, 10-18.
Paul A. Wender, Robert J. Ternansky, and Scott McN. Sieburth, "An Enolate-Accelerated Cope Rearrangement." Tetrahedron Letters1985, 26, 4319-4322.
Paul A. Wender, Dennis A. Holt, and Scott M. Sieburth, "Practical Method for alpha-Alkenyl Ketone Synthesis Based on a Facile Reductive Rearrangement of Alkynyl Halohydrins." Journal of the American Chemical Society1983, 105, 3348-3350.
Paul A. Wender, Scott McN. Sieburth, Joseph J. Petraitis, and Sunil K. Singh, "Macroexpansion Methodology: Medium Ring Synthesis Based on an Eight Unit Ring Expansion Process." Tetrahedron1981, 37, 3967-3976.
Paul A. Wender and Scott McN. Sieburth,"Macroexpansion Methodology: An Efficient Eight Unit Ring Expansion." Tetrahedron Letters1981, 2471-2474.
S. M. Sieburth. "Substituted Phenyltrialkylsilane Insecticides."US Patent 4,709,068 1987 [Chemical Abstracts 108:94775e].
G. A. Meier, S. M. Sieburth, T. G. Cullen, J. F. Engel "Insecticidal Cyclopropyl-substituted Diaryl Compounds." WO Patent 8,808,416 1988[Chemical Abstracts 110: 134868n].
T. G. Cullen, S. M. Sieburth, G. A. Meier, J. F. Engel. "Insecticidal Cyclopropyl-substituted Di(aryl) Compounds."US Patent 4,808,762. 1989.
S. M. Sieburth. "Substituted Phenyltrialkylsilane Insecticides."US Patent 4,883,789 1989 .
T. G. Cullen, S. M. Sieburth, G. A. Meier, J. F. Engel, L. W. Stratton, A. W. Fritz. "Preparation of Insecticidal and Acaricidal Cyclopropyl?diaryl?butenes."US Patent 4,975,451 1990 [Chemical Abstracts114:184953q].
T. G. Cullen, S. McN. Sieburth, G. A. Meier, J. F. Engel. "1,4-Diaryl-1-Cyclopropyl-4-Substituted Butanes as Insecticides and Acaricides"US Patent 5,223,536 1993.
S. McN. Sieburth, A. M. Mutahi, and Chien-An Chen. "Silanol Hydrolase Inhibitors"US Patent application 08/680,330 1996.
S. McN. Sieburth, A. M. Mutahi, and Chien-An Chen. "Silanol Enzyme Inhibitors"WO 9802578 A1, 1996.
S. McN. Sieburth, A. M. Mutahi, and Chien-An Chen. "Silanol Enzyme Inhibitors" US Patent 6,441,212 2000